Chronic Conditions and Autoimmune Diseases

Autoimmune diseases are a condition where the body's own immune system mistakenly attacks its own cells and tissues. Normally, the immune system’s role is to guard the body from the attacks of bacteria, viruses, and other germs. In the case of autoimmune diseases, however, the immune system mistakes the normal, healthy parts of the body for foreign ones and invades them. This can result in inflammation, damage to tissues, and dysfunction of organs. Generally, the diseases continue throughout a person’s entire life, although their severity may differ at times. Some people have periods when their symptoms are mild or absent, while others experience relapses, where the symptoms become more severe.

Due to the fact that autoimmune diseases are a condition where the immune system attacks the body’s own tissues, most of them require long-term management. The general treatment strategy for most of these diseases is to control inflammation, manage symptoms, and to slow the progression of tissue damage. However, many autoimmune diseases cannot be cured, which is why they are considered chronic. There are many different types of autoimmune diseases, and they can affect various parts of the body, including the skin, joints, organs, and blood vessels. Here, we will go through the three most common autoimmune diseases.

Rheumatoid Arthritis

This is an autoimmune chronic disease which affects the joints; mostly the hands, wrists, and knees. Rheumatoid arthritis occurs when the immune system attacks the synovium, which is the lining of the membranes that cover these joints. It causes inflammation, pain, stiffness, and at worse destroys the joint. Symptoms include swollen, tender and red joints. The exact cause is unclear, but a genetic predisposition and environmental factors (such as smoking) are thought to contribute. Women are also more likely to develop rheumatoid arthritis than men.

Type 1 Diabetes

Type 1 diabetes is an autoimmune disease where the immune system attacks and destroys the insulin-producing beta cells in the pancreas. Insulin is a hormone which is essential in the process of regulating blood sugar (glucose) levels. Without insulin, blood sugar levels can rise dangerously high. Symptoms include increased thirst and urination, as well as an excessive appetite or sudden extreme weight loss.

Treatment often involves lifelong insulin therapy, either through injections or an insulin pump,in order to regulate blood glucose. Blood sugar levels must be monitored frequently to prevent complications, such as long-term damage to organs.

Multiple Sclerosis

Multiple sclerosis is an autoimmune disease that affects the central nervous system, including the brain and spinal cord. The immune system attacks the protective myelin-sheath which covers nerve fibers, and this causes inflammation and damage. Thus, the transmission of nerve impulses are damaged, leading to a wide range of neurological problems. Symptoms include numbness or weakness in limbs. This can lead to difficulty walking or maintaining a sense of balance, which often results in uncontrollable muscle

spasms. The exact cause of muscular sclerosis is unclear, but it is widely believed to be a combination of genetic susceptibility and environmental factors, such as viral infections. MS is more common in women, and symptoms often begin in young adulthood. There is no cure for the debilitating disease, treatments aim to manage symptoms, reduce relapses, and slow disease progression.

Due to autoimmune diseases being so common and often resulting in a significantly lower quality of life for those affected, treatments are constantly being pioneered. The main areas of advances in treating autoimmune diseases are focused on targeted therapies and personalized medicine. Treatments such as biologics, encompassing JAK inhibitors, monoclonal antibodies, and interleukin inhibitors, have dramatically altered the treatment for rheumatoid arthritis and psoriasis specifically by attacking specific immune molecules. Personalized medicine, which is inspired by a deepening genetic understanding, plays a vital role in the personal tailoring of treatments for best outcomes. Furthermore, stem cell therapies, such as hematopoietic stem cell transplantation, show promise in resetting the immune system, while advances in the microbiome open new avenues in modulating immune responses. Together, these developments offer more effective and individualized approaches to managing autoimmune diseases.

In conclusion, autoimmune diseases are complex and chronic conditions which require ongoing management. While there is no cure for a majority of these diseases, recent breakthroughs in biologics, personalized medicine and stem cell therapies are offering a new sense of hope. With these advancements, patients now have more options to manage their symptoms and improve their quality of life, making it a very exciting time in autoimmune disease treatment and research.

Written by Nawal

Moderated by Adelene

References:

Mount Sinai Health System. (n.d.). Autoimmune disorders Information | Mount Sinai - New York. [online] Available at:

https://www.mountsinai.org/health-library/diseases-conditions/autoimmune-disorders.

Hopkinsmedicine.org. (2024). Precision Therapies for Autoimmune Diseases.[online] Available at:

https://www.hopkinsmedicine.org/news/articles/2024/02/precision-therapies-for-autoimmune-diseases.

Medline Plus (2017). Autoimmune disorders: MedlinePlus Medical

Encyclopedia. [online] Medlineplus.gov. Available at:

https://medlineplus.gov/ency/article/000816.htm.

Mayo Clinic (2023). Rheumatoid Arthritis - Symptoms and Causes. [online]

Mayo Clinic. Available at:

https://www.mayoclinic.org/diseases-conditions/rheumatoid-arthritis/symptoms-causes/syc-20353648.

MS Society (2022). What is MS? [online] Mssociety.org.uk. Available at:

https://www.mssociety.org.uk/about-ms/what-is-ms.

Cleveland Clinic (2022). T ype 1 diabetes. [online] Cleveland Clinic. Available at: https://my.clevelandclinic.org/health/diseases/21500-type-1-diabetes